This already adopted medicine can stop the worst food reactions

Food allergies absorbs. Besides setting arduous limits on your diet, its health effects can completely come out of the course of your life, and scientists have been scrambling for years to try to find better and more permanent treatments for the worst of these conditions. Now, a couple of leaves published today in Science opens new, decisive visions about what is going on in the body when excessive sensitivity occurs and indicates how the medications present one day can help prevent life -threatening allergic reactions.

in OneA team of scientists reveals evidence in laboratory mice on an unknown path in the intestine that may be responsible for some symptoms of food allergies. In Second paperAnother team explains that asthma is called Zileuton prevents an important aspect of this path in mice, apparently prevents the expected allergic reactions from occurring in most cases. Researchers now call a clinical trial to test whether Zileuton can withdraw the same trick in people.

“If so, this may provide a treatment to prevent excessive allergies,” Adam James Williams and Stephanie Eisenbright, both of whom are immune scholars in Northwestern University Who are the authors participating in the second paper, tell Gizmodo in an email.

Scientists have worked for years to solve a puzzling puzzle: Why do not some people who have tested positively do not develop food sensitivity when they are exposed to trigger foods, while others develop with the same allergic allergy?

Researchers describe a gene called DpeP1 and appears to play a sudden role in controlling the excessive sensitivity of food in mice: the gene seems to be organizing leukemia in the intestine-these particles that help stimulate an immune response to allergies.

When we eat food, most of them are divided into nutrients for the use of the body. But some small amount through the intestine is transferred to the blood as complete proteins, and these whole proteins that can lead to a reaction in a person who is allergic to food. “We have found unexpectedly that lucotine in mice controls the amount of whole proteins that are transferred across the intestine, even in an unhealthy state of healthy,” the authors of the study explained. Scientists have already known that the lucotine played a role in causing asthma attacks and many asthma treatments, including zileuton, working by preventing the activity of these molecules.

Then the researchers gave a dose of Zileuton to mice that were allergic to peanuts and then exposed them to their operating food. They found that the medicine prevented lucotine in the intestine of mice from working as usual, which reduces the possibility of an allergic reaction. The researchers told that 95 % of doses mice failed to show any sign of excessive sensitivity.

Studies in mice, how can the results be translated into people still needed. Authors also warn that Zeloton is not a treatment for food allergies. However, if human trials involve what was seen in mice, the drug can be used as a prevention that some people can take before a highly dangerous situation as they are likely to be exposed to such foods. It is worth noting that many people already take Zileuton daily to maintain long -term asthma symptoms, indicating its safety, although it is unclear how its long -term use affects the intestine.

If the ongoing clinical experience in humans succeeds in showing the same path as in mice, researchers are planning to test the ability of the drug directly to prevent excessive sensitivity in people with food allergies. The researchers said that in addition to clinical applications, the research raises other questions.

“There are many other exciting questions, such as if this path is organized by things in our environment, such as changes in the microbium caused by the diet,” said Williams and Isenbarte.