A new gel can heal stubborn diabetes in less than two weeks

For people with diabetes, high blood sugar can harm blood vessels and nerves, which leads to chronic wounds that remain open for several months. But the new gel -based treatment can greatly accelerate the healing process for people with diabetes, allowing closure in only days, according to a new study.

The new treatment is targeted by Dhrombospondin-1 (TSP-1), a protein that prevents the growth of new blood vessels, which is a decisive step in the healing process. The targeting of this protein has increased the formation of new blood vessels in human ventricular cells and in diabetic mouse models, which leads to a wonderful wound closure rate in less than two weeks. A team of researchers from various institutes in China revealed the new technology in a study published in the magazine Burns and shocks.

“Our results show the strength of the combination of advanced tissue engineering and molecular biology. By targeting TSP-1 with SEVS Mir-221oe covered in GELMA, we not only improved the function of the blanket cells in the fourth medical center of Pla General statement.

Diabetes wounds have increased TSP-1 levels in lining cells, and cells that line blood vessels, according to previous studies. TSP-1 hinders their ability to divide and go as they need to go. Study researchers have developed a way to reduce TSP-1 levels.

This technique uses small vesicles outside the cell (SEVS)-pre-teenage bags that are usually released by cells-loaded using Mir-221-3p, which is Microrna that disrupts the production of TSP-1 in lining cells.

The researchers packed this SEVS in hydrogel, which mimics the environment outside the cell and provides a continuous and dominant version of the Mir-221-3p at the wound site. In diabetic mouse models, gel accelerated significantly, which led to a 90 % wound closure rate within 12 days – only 20 % in unparalleled mice during the same period.

The following steps are to bring the new gel to clinical trials, according to the authors. “This achievement can revolutionize how we deal with the care of a diabetic wound, with the ability to significantly improve the quality of patients’ life,” Shin said in a statement.