The researchers create a three -dimensional prosthetic skin that allows the blood circulation

When severe treatment Burns and shocks, skin regeneration can be a matter of life or death. Wide burns are usually treated by planting a thin layer of skin, the upper layer of the skin, from another place on the body. However, this method leaves not only large scars, but also does not return the skin to its original functional state. Unless the dermis, the layer below the skin, which contains blood vessels and nerves, cannot be considered a natural live skin.

Now, work by Swedish researchers may have approached the ability to renew live skin. They have developed two types of 3D biotechnology to generate artificial thick skin that are strengthened, which means that it contains blood vessels. One technique produces a skin full of cells, and the other produces an arbitrary blood vessel in the tissues. The two technologies take different approaches to the same challenge. The approach was determined in two studies Posted in the Journal of Advanced Healthcare materials.

“The dedication is so complicated that we cannot grow it in a laboratory. We do not even know what its components are,” said Johan Johnker, associate professor at the University of Lincocoking and a plastic surgery specialist who led this work. statement. “That is why we, and many others believe that we can plant building blocks and then let the body make the brains themselves.”

Linköping team using BIOPRINTERN 3D.

Photo: Magnus University Johansson/Lining

Junker and his team designed a vital follow-up called “μINK” where the fibroblasts-which produce skin components such as collagen, elastin and hyaluronic acid-are raised on the surface of small sponge gelatin granules covered with hyaluronic acid. By building this 3D ink using a 3D printer, they managed to create a skin -filled with high -density cells at the will.

In the transplant experience using mice, the researchers emphasized that living cells have grown inside the tissue fragments made of this ink, which secretes collagen and rebuilding the components of the dermis. The new blood vessels have also grown inside the illegal gain, indicating that the conditions for fixing long -term tissue have been met.

The blood vessels play a very important role in building artificial tissues. Regardless of the number of cultivated cells to create a tissue model, without blood vessels, oxygen and nutrients can not be evenly transferred to all cells. Without the blood vessels, with the growth of the tissue structure, the cells in the middle of the tissues die.

The research team has also created a technology called (hanging hanging hydrogen strands), which allows the construction of flexible blood vessels in the artificial tissues by printing and arranging hydrogel strands by 98 percent. These strands are tougher than regular gel materials and can maintain their shape even when tied or braided. Moreover, they also have a memory properties that allow them to return to their original shape even when crushed.