Dental thread can provide vaccines from the next generation, and there are no required needles

The influenza snapshot season is just around the corner, and while the injection remains the most common shape vaccinationScientists work hard to find other ways to deliver vaccinations that do not include a needle in your body. In a new study, researchers believe that they may find another new approach: dental thread.

In the new work, a team of scientists in the United States showed how this could work in laboratory mice, and found that connecting vaccines via the tooth thread was more effective in stimulating the production of antibodies than if the vaccine was delivered under the tongues of mice and about effective such as the way to deliver nasal spray. If the results are correct for humans, some vaccines can be given via the toothpick and without the need for needles.

The researchers wrote in the study: “We explain here that the flat tooth thread can provide vaccines through the connecting epithelium of the gums, and the exploitation of its naturally leaked properties.” The nature of biomedical engineering. The connection epithelium is the technical term for the deep tissue between the tooth and the gums. The epithelial tissue is one of three layers of the so -called Mucous The surfaces, which are the membranes that follow and protect your body and cavity, including your nose, mouth and intestine. Many pathogens such as Influenza and Covid-19 It can enter the body through these mucous surfaces.

“If a vaccine is given by injection, antibodies are produced primarily in the bloodstream throughout the body, and relatively few antibodies are produced on mucous surfaces,” explained by Harpers Singh Jill, a co -author of the study and professor in Nanomidisin in North Carolina, explained in A. statement. “But we know that when a vaccine is given across the surface of the mucous, the antibodies are stimulated not only in the bloodstream, but also on the mucous surfaces.”

He added: “This improves the body’s ability to prevent infection, because there is an additional line of defending antibodies before the nurse enters the body.”

Because the tissues between our teeth and gums are more accessible than other similar tissues, such as those that lined your stomach, lungs and intestine, you must be able to serve Vaccine In the body easily, which leads to the production of antibodies throughout the mucous layers. To test this idea, the researchers applied the peptide influenza vaccine to the unusual tooth thread, then used it for laboratory mice thread.

Then the gills and his colleagues compared the production of antibodies with mice that received peptide influenza vaccine through nose spray or under its tongues. The tooth thread vaccine delivered the production of superior antibodies to the mucous surfaces of pollination under the tongue, and it was similar to the spray of the nose.

“This is very promising, because most vaccine combinations cannot be given by the nasal epithelium – the barrier features in this mucous surface prevent the absorption of the effective vaccine,” Gil said, adding that the nasal birth also carries the risk of reaching the brain, which may put safety concerns. “Vaccination through the connection epithelium does not provide any such risk,” he said.

The team also tested a thread approach with three other vaccines categories – proteins, broken viruses, and MRNA – and revealed that the method of the novel caused antibodies in both the bloodstream and mucous surfaces in each of them. What is more, their effectiveness is not obstructed if mice consume food or water immediately after the thread.

To investigate the practical application of the thread approach, the researchers also tested its mechanics with humans. Using the thread choices, they wrapped the tape with the food dye and asked the study participants to try to get it deeply between their teeth and gum as much as possible. Participants were able to deposit about 60 % of the dye in the gum pocket, indicating that the choices of the vaccine thread can be an effective way to provide vaccines for these tissues.

For costs, the researchers believe that it will be similar in the prices of other vaccine delivery technologies. However, there are some restrictions inherent in the thread vaccine.

“For example, it can only be used for individuals who have teeth,” the study researchers explained. “Therefore, this approach cannot be used in newborns (newborns) until they suffer from tooth eruption, which usually occurs at about 6 months. Moreover, the effect of gum tissue infection on vaccination is unclear. Additional studies are needed to answer this question.”