People associated with excessive factions who may help open sleep stopping treatments better

But searching for such a pill – or in reality any effective treatment like CPAP – has proven to be difficult. Dozens of drugs It failed to show the event In clinical trials, while HGNS was first approved by the US Food and Drug Administration in 2014, Miller says his proposal is limited, as many doctors are not sure of the risk comparison to the return. “The device is very expensive, and the implant requires surgical procedure,” which explains, which comes with an additional risk of the patient. “As with any new technology, there is often a delay in accepting both the medical community and insurance companies.”

It is unlikely that one treatment is found as a substitute for CPAP, as Gaish argues, because sleeping during sleep is not a single disease – a variety of cases. Obesity is known to be one of the main risk factors-and the drug-losing drugs It was recently licensed As a treatment for breathing during sleep – excessive fats around the neck and the upper body can hinder the airway and cause breathing stops. But there are many other reasons, some of which appear recently. Researchers have now begun to understand the effect of ethnicity on sleep apnea, for example, with patients in Asia in Increased risk.

Gaisl says: Sleep breathing is “mosaic from different things, not only obesity.” “We are increasingly seeing that different sub -groups benefit more than more specialized methods.”

This recognition prompted researchers to focus more on EDS residents. Gaisl estimates that just the presence of EDS is equivalent to an increase in the body mass index by 11 points in terms of the possibility of developing breathing during sleep. This is because the genes associated with EDS affect the structure of the so-called “matrix proteins” such as collagen and elastin, which provide a frame of the connective tissue of the body-everything from the skin to the tendons, muscles and ligaments.

“Collagen is an integral part of almost all tissues, including those that make up the airway,” says Karim Gobroeer Sidki, an assistant professor at Drexelle University and a sleep specialist who treated sleep during sleep. “In two editors, this anomaly in collagen is what makes the airway more likely to collapse when a person breathes.”

For this reason, the researchers believe that sleep -stopping patients are particularly suitable for treatments that target muscles in the tongue and throat – such as HGNS Miller, or a newer drug mixture under development by a company called APNIMED. Based on the discovery that two vehicles, o ormoxine and oxibutine, they can work in synergy to improve the color of the upper airway muscle and reduce the relaxation of the airway muscles during sleep, nearby breathing has been shown In a clinical trial To reduce sleep stops during sleep by 56 percent. “People with hyperactivity are a major targeted group of these types of treatments,” says Gissel.

while They were released for a long time rareRecent studies Suggest Hyperactive genetic mobility may affect up to 1 in 500 people, as women are not affected by a proportional manner. Gaisl believes that the basic biology behind these conditions also provides evidence to explain other sub -species to stop breathing during sleep. From his point of view, genetics in EDS reflects the activity of the damage that others unintentionally suffer from matrix proteins through environmental behaviors and stresses such as smoking, chronic inflammation, excessive dietary sugar, and the aging process itself, which increases the risk of breathing during sleep to the middle.

“EDS is a kind of natural experience that gives us an insightful look at some of the main biological mechanisms behind sleep breathing that are persuaded in the general population,” says Gissel.

These individuals can benefit more than targeted treatments such as HGNS or APNIMED drugs, compared to patients led by breathing in the first place from weight gain or basic breathing deformities. The latest diagnoses apply artificial intelligence algorithms to patient sleep data, which spoils major patterns indicating a specific type of airway collapse. In the future, these tools can help doctors to identify these people faster and more accurate, as well as individuals who suffer from unlicensed hyperactivity. These ideas can then be used to customize their treatment.

While the researchers learn more about the role of the spinning proteins in the sleep -related sleep -related sleep, it may pave the way for completely new treatments in the future.

“This opens up a new way for treatments that may target how connective tissue is affected by time, causing sleep breathing – treatment that can ultimately benefit a wider group of patients.”