Tube transplants are not all cracked

Stool back like A possible treatment for a wide range of casesIncluding irritable bowel syndrome, diabetes, and even depression. This alleged tube transplant has received a lot of attention, but new research has a little glimpsed of a blanket damping this practice.

The procedure includes taking microbes from a good healthy tube Transfer them to the colon to the patient. This must restore balance to the intestine microbiome, but according to a study published on June 6 in the magazine cellThe cultivated microbes may colonize the wrong parts of the digestive system. This can lead to a long front Unintended health consequencesThe researchers warn.

“I think it is an invitation to wake up to this field, we may not put the large bowel microbes in different parts of the intestine that should not be there,” He said The main author Orlando “Landon” Delon, post -doctoral researcher at the University of Chicago, in a statement.

Deleon has led a team of researchers through a series of experiments on mice to determine how the implants of stroke affects different parts of the intestine. Mice are separated into three groups. One of the microbes received from Jejunum (the middle part of the small intestine), the second microbes received from the CECUM (a bag connecting the small intestine to the colon), and the third received the standard stool from the colon.

Each part of the digestive system has uniquely air -conditioned microorganisms. The researchers wanted to know if the microbes would stick to their outlets once in the mice. In fact, they found that each of the transplants has successfully colonized the full intestinal system, creating the “incompatibility” of the regional intestine that lasted for up to three months after the procedure.

The microbes that colonized parts of the intestine have led to metabolic changes in these intestinal areas, with the ability to affect the patient’s health and behavior. The researchers have noticed changes in eating, activity and energy expenses in mice after transplants. They also documented the changes in the activity of the genes associated with the immunity function, which in turn led to changes in liver metabolism. The most surprising thing was the way these foreign microbes changed from genetic expression and protein in the intestinal lining to make the inconsistent bowel area more suitable for them.

“It seems as if they were geometric or raised their environments to help them suit,” said Delon.

To determine whether this mismatch can occur in actual stool transplant patients, he and his colleagues conducted additional tests using human tissue samples. The results showed that cultivated intestinal bacteria can colonize parts of the human digestive system as they do not belong naturally.

“If we designed good treatments, we must be aware of the importance of matching regional microorganisms with their appropriate environments, so that we provide health benefits in general better,” said Delon. For example, the results indicate that it may be safer to use microbes that are recovered from all parts of the digestive system, according to researchers.

Food and Drug Administration (FDA) only Recommend Stool transplants for Treating frequent infections Clostridium is difficultOr C. DIFF. These bacteria – which can cause severe digestive symptoms – are mostly hospital patients who have been treated with antibiotics. Stool Stabilize To be very effective to treat these infections, and these results encouraged researchers to investigate other applications for this procedure.

A wave of new research indicates that stool transplants can treat cases that exceed the intestine. In fact, studies have found that this procedure can benefit patients with Nervous growth and Psychological disordersand Multiple stiffnessType 2 diabetes, and more.

Deleon’s results indicate that doctors need to understand the risk of cultivation of fecal materials better before using this treatment for other diseases other than C. DIFF. He plans to continue how different microbes affect each part of the intestine and explore ways to restore changing areas to their original state.

This study shows that when it comes to intestinal microbes, the site is really important. Obtaining appropriate errors in the right place may open the full potential of stool transplants.