3 Scientists win the Nobel Prize in Medicine for Discoveries in Immunology

Stockholm – Mary E. Branco, Farid Ramzdale and Dr. Shimon Sakajui, Nobel Prize in Medicine, on Monday for their discoveries related to peripheral immune tolerance.

Branco, 64, is the director of a great program at the Biology Institute in Seattle. RAMSDell, 64, a scientific advisor for Sonoma Biotherapics in San Francisco. Sakajucci, 74, a distinguished professor at the Immunical Border Research Center at the University of Osaka in Japan.

Branco received the news of her prize from AP photographer who came to her home in the early hours of the morning.

She said she ignored the previous invitation from the Nobel Committee. “I ran my phone and saw a number of Sweden and thought:” This is only, this random mail of some kind. “

Her husband, Ross Kolkonon, said: “When Mary told she won, she said:” Don’t be ridiculous. “

“It was a nice surprise,” Sakajucci told a press conference from the University of Osaka in western Japan. “I hope for research in the region so that our results can be used in treatment, and I hope we can contribute to this as well.”

The immune system contains many overlapping systems to detect bacteria, viruses and other bad actors. Main immune warriors such as T -cells are trained on how to discover bad actors. If some of this goes instead in a way that may cause autoimmune diseases, it is supposed to be eliminated in the thymus gland – a process called central tolerance.

The Nobel winners revealed an additional way that the body keeps the system.

The Nobel Committee said it had begun to discover Sakajuchi in 1995 for a sub-type of T-Magazine, which is not previously known as the organizational cells or T-REGS. Then in 2001, Brunkow and RAMSDELL discovered the perpetrator’s boom in a gene called Foxp3, a gene that also plays a role in rare human autoimmune disease.

The Nobel Committee said two years later, Sakagucci linked the discoveries to show that the Foxp3 gene controls the development of those T-REGS-which in turn works as a security guard to find and other forms of T-cells that exaggerate their response.

Branco said that she and Amsdel are working together in a small biotechnology company and they were investigating the reason for a certain strain of mice in the excessive active immune system. They had to work with new techniques to find the mouse gene behind the problem – but they soon realized that he might be a major player in human health as well.

“From the DNA level, it was a really simple change that caused this tremendous change in how the immune system works.”

Mary and Lennus, a professor of rheumatology at the Carolinska Institute, said the work opened a new field of immunology. Researchers all over the world are now using organizational T cells to develop treatments for autoimmune and cancer.

“Their discoveries were crucial to our understanding of how the immune system works and why not all develop serious immunity diseases,” said Ully Camp, head of the Nobel Committee.

The award is the first of the Nobel Prize 2025 ads and announced a committee at the Carolinska Institute in Stockholm.

Nobel ads with the Physics Award will continue on Tuesday, chemistry on Wednesday and literature on Thursday. The Nobel Peace Prize will be announced on Friday and the Nobel Memorial Prize in the economy on October 13.

The award ceremony will be held on December 10, the anniversary of the death of Alfred Nobel, who established the awards. The Nobel Swedish Industrial was the wealthy and inventor of dynamite. He died in 1896.

The trio will participate in the prize funds of 11 million Swedish kronor (about $ 1.2 million).